The Center for Pediatric Immunology at Washington University and St. Louis Children’s Hospital, with funding from the St. Louis Children’s Hospital Foundation, seeks to provide an infrastructure that will enable the genetic diagnosis of pediatric patients with inborn errors of immunity. The center focuses on using state-of-the-art sequencing technologies available through the McDonnell Genome Institute combined with functional studies of the immune system to provide insight into why children have immune dysregulation. The long-term goal of the center is to provide children with immune system disorders a target that can be therapeutically treated.

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Deficiencies and Dysregulation of STAT Pathways That Drive Inborn Errors of Immunity: Lessons from Patients and Mouse Models of Disease

May 15, 2023

Toth KA, Schmitt EG, Cooper MA. Deficiencies and Dysregulation of STAT Pathways That Drive Inborn Errors of Immunity: Lessons from Patients and Mouse Models of Disease. J Immunol. 2023 May 15;210(10):1463-1472. doi: 10.4049/jimmunol.2200905. PMID: 37126806; PMCID: PMC10151837.

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